Background.According to present views proliferation and apoptosis plays an important role in the mechanisms of placenta formation, particularly in process of vasculogenesis that begins on the third week of pregnancy.Objective: To investigate the immunohistochemical features of chorion and endometrium in women with early pregnancy losses.Methods.98 samples of abortive and surgical material inflatable-dildos in pregnant women in terms of 4-10 weeks of pregnancy were analyzed.
48 samples were obtained from women with missed abortion (1st group), 20 samples from women with spontaneous abortion (2nd group); 20 samples from women with tubal pregnancy (3rd group); 10 samples from pregnant women with normal singleton pregnancy, after medical abortion on their own wish (control group).Histological, histochemical and immunohistochemical methods were used.Monoclonal antibodies (MAbs) to Ki-67 and bcl-2 were applied.Results.Pathological picture of spontaneous abortion is characterized by the dominance of violation of blood circulation, presence of significant foci of hemorrhage occurring parallel with a pronounced disruption of apoptosis and proliferation in chorionic villi and decidual tissue, leading to the detachment of placenta.
Conclusion.In 75% of cases of tubal pregnancy ectopic cytotrophoblast invasion is caused by prominent changes in the structure of the fallopian Dishwasher Kick Panel tube.First of all due to the inflammatory process and a sharp reduction of proliferation in the basal chorion and parietal deciduitis in 65% of cases.Citation: Trohimovych OV.[The immunohistochemical features of chorion and endometrium in women with early pregnancy losses].
Morphologia.2015;9(1):58-64.Russian.